erapy already authorised for diabetes treatment, can assist cut back physique weight in folks with weight problems when used at

Diabetes Drug Could Spur Weight Loss In Overweight Nondiabetics

May 30, 2014 by Steven Reinberg, Healthday Reporter
One-third who took Victoza misplaced 10 percent of physique weight, researchers say.
(HealthDay)—A better dose of the diabetes drug liraglutide (Victoza) may assist overweight people with out the illness shed pounds, a new research suggests.
In this test of its effectiveness as a weight loss plan aid, people taking liraglutide for over a yr lost a median of eight p.c of their physique weight, in contrast with 2.6 % shed by these taking a placebo (dummy drug), researchers discovered.
Victoza/liraglutide is often given in 1.2 milligram and 1.eight milligram doses as a diabetes remedy. Within the new examine, aimed at seeing if the medication may assist curb obesity, the drug's dose was upped to 3 milligrams.
"Liraglutide, an injection therapy already authorised for diabetes treatment, can assist cut back physique weight in folks with weight problems when used at the next dose than is usually utilized in diabetes," said lead researcher Dr. John Wilding, head of the division of obesity and endocrinology on the College of Liverpool in England.
"These outcomes suggest liraglutide is effective and general nicely-tolerated for obesity remedy," he said.
Though this examine did not examine Victoza with different weight reduction drugs , Wilding said that a earlier examine confirmed Victoza may produce about twice as a lot weight reduction as one other drug, orlistat (Xenical).
Xenical works by reducing the quantity of fat the intestines can absorb. Individuals taking Xenical lose a mean of five to seven pounds, studies have shown.
The outcomes of the examine were scheduled for presentation Thursday at the European Congress on Obesity in Sofia, Bulgaria. Knowledge and conclusions introduced at meetings are usually thought of preliminary till revealed in a peer-reviewed medical journal.
Dr. David Katz, director of the Yale College Prevention Analysis Center in New Haven, Conn., wasn't stunned by the findings. "A number of drugs used to deal with sort 2 diabetes have a tendency to supply weight reduction as one of their results," mentioned Katz, who was not involved in the research.
That is predictable as a result of the insulin resistance that precedes and often accompanies type 2 diabetes leads to frequent starvation and weight acquire. Decreasing blood sugar leads to weight reduction, he stated.
Whether or not Victoza improves long-term weight management or results in better health outcomes over years when used for weight reduction is unknown, he mentioned.
"However for now, Victoza takes its place alongside different medicine studied initially for diabetes , but found to be probably helpful for weight reduction as nicely," Katz mentioned.
"Such drugs will never substitute diet and bodily exercise, but could prove a reasonable addition to lifestyle intervention in some patients," Katz added.
For the research, Wilding and colleagues randomly chosen more than 3,700 overweight and overweight adults to take each day injections of Victoza or a placebo. The contributors' average age was forty five.
Folks in both teams also followed a weight loss program containing 500 fewer calories than a normal eating regimen. They usually had to enhance bodily activity by walking briskly for half-hour a minimum of five instances a week.
Many participants (61 %) had blood sugar ranges that made them prediabetics, however none had full-blown type 2 diabetes , the researchers famous.
The researchers found that nearly two-thirds of these taking Victoza lost 5 % or extra of their body weight, and one-third lost 10 % or more. Amongst these taking the placebo, 27 percent lost 5 p.c of their body weight or more, and one in 10 lost 10 percent or extra.
Folks taking Victoza also saw a drop in their blood sugar, blood strain and ldl cholesterol, the study found.
Primarily based on these section three trial findings, drug maker Novo Nordisk is asking the U.S. Meals and Drug Administration to approve Victoza for weight loss Section three is the ultimate step in the drug-approval process.
The commonest unintended effects have been nausea and diarrhea. Most of those had been delicate and brief-lived, the researchers mentioned.
Gallbladder and pancreas issues (pancreatitis) had been extra widespread amongst those taking Victoza, but the numbers have been small. About 10 p.c of the participants in both groups left the research because of unwanted effects.
Wilding has served as a consultant to Novo Nordisk, which funded the research.
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